Tuberkulosis Laten pada Tenaga Kesehatan di RSI Jemur Sari Surabaya
Abstract
Abstrak
Latar belakang: Prevalensi TB paru dengan konfirmasi bakteriologis sebesar 759 (95% CI589-961) per 100.000 penduduk yang berumur 15 tahun ke atas. Petugas kesehatan yang bekerja di bagian paru rumah sakit, sangat rentan terpapar kuman Mycobacterium tuberculosis, dikarenakan setiap hari ada hubungan/ kontak dialog (anamnesis) dengan penderita tuberkulosis aktif yang sedang berobat. Tujuan penelitian ini adalah untuk mengetahui prevalensi TB Laten pada tenaga Kesehatan dengan metode IGRA
Metode: Metode penelitian deskriptif dengan sample adalah seluruh tenaga kesehatan di bagian paru RSI Jemur Sari terdiri dari 2 dokter, 2 analis dan 6 perawat, terutama yang telah bekerja lebih dari 5 tahun diambil darahnya untuk diperiksa antibodi interferon gamma dengan metode IGRA.
Hasil: Hasil penelitian didapatkan dari 10 sampel yang berhasil dilakukan pemeriksaan didapatkan 70% tenaga kesehatan yang kontak dengan penderita positif antibodi interferon gammanya.
Kesimpulan: Kontak dengan penderita Tuberkulosis yang terus menerus memungkinkan tertular, dimana imunitas yang baik dapat menyebabkan tenaga kesehatan tersebut tanpa gejala dan keluhan.Diperlukan penatalaksanaan administratif yang baik agar dapat menurunkan angka kejadian tuberculosis laten
Kata Kunci : IGRA, Tenaga kesehatan, Tuberkulosis laten
Abstract
Background The prevalence of pulmonary TB with bacteriological confirmation was 759 (95% CI589-961) per 100,000 population aged 15 years and over. Health workers who work in the pulmonary section of the hospital are very susceptible to exposure to Mycobacterium tuberculosis, because every day there is a relationship/contact dialogue (anamnesis) with active tuberculosis sufferers who are being treated. The purpose of this study was to determine the prevalence of latent TB in health workers using the IGRA method
Method Descriptive research method with samples were all health workers in the pulmonary section of RSI Jemur Sari consisting of 2 doctors, 2 analysts and 6 nurses, especially those who had worked for more than 5 years had their blood taken for examination of interferon gamma antibodies using the IGRA method.
Results From 10 successfully examined sample, 70% of the health workers that has contact with the patients has positive interferon gamma antibody.
Conclusion Prolonged contact with Tuberculosis patient raises the probability of contagion, whereas decent immunity allows the health workers to proceed without any symptoms. An excellent administrative governance is required to reduce the occurrence of latent tuberculosis.
Keywords : Health workers, IGRA, Latent tuberculosis
References
Kemenkes RI. Survei prevalensi tuberkulosis 2013-2014 Indonesia. 2015.
World Health Organization (WHO). Global tuberculosis report. Geneva; 2014.
Pulungan RM, Permatasari P. Predisposing and Enabling Factors Relationship with Successful Treatment of Pulmonary Tuberculosis (TB). J Kesehat Prima. 2021;15(1):57.
Maharani R, Karima UQ, Kamilia K. Socio-demographic and Behavioral Factors Relationship with Pulmonary Tuberculosis: A Case-control Study. Open Access Maced J Med Sci. 2022;10:130–5.
Nurhakim AD, Harfiani E, Mashoedojo. Faktor Apa yang Mempengaruhi Rendahnya Tingkat Pengobatan Tuberkulosis di Lagoa Jakarta? What Factors Affect Low Rates of Tuberculosis Treatment in Lagoa Jakarta? J Ilm Kesehat Masy [Internet]. 2020;12(3):2020. Available from: https://jikm.upnvj.ac.id/index.php/home/article/view/80
R WOW. Tuberkulosis : diagnosis dan tatalaksananya. Perhimpunan Dokter Paru Indonesia. 2014.
Surjanto KS. Uji tuberkulin. Bagian Pulmonologi dan Kedokteran Respirasi FK UNS/ RSUD Dr. Moewardi Surakarta. 2012;
Heru S. ESAT 6 pada diagnosis tuberkulosis laten tenaga kesehatan. Airlangga Univ Press. 2016;
Lopez. Influence of the interferon-gamma (IFN-γ) and tumor necrosis factor alpha (TNF-α) gene polymorphisms in tuberculosis occurrence and clinical spectrum. Intech. 2013;79–103.
Hermayanti D. Respons imun dan pemeriksaan serologi pada tuberculosis. Fak Kedokt Univ Muhammadiyah Malang. 2014;
Soto H, Leetola C, Huang J, LeFevre N JS. Bioassay development of cytokines produce by Th 17 cells. J Immunol. 2015;182(42).
Murad H M-NN. Pattern recognition receptors and cytokines in Mycobacterium tuberculosis infection. Biomed Res Int. 2013;
Varahram M, Farnia P, Nasiri MJ, Karahrudi MA, Dizagie MK et al. Association of Mycobacterium tuberculosis lineages with IFN and TNF-a gene polymorphisms among pulmonary tuberculosis patient. Mediterr J Jematol Infect Dis. 2014;6(e201415).
Corbiere, Pottier B. Risk stratification of latent tuberculosis defined by combined interferon gamma release assays. PLoS One. 2012;7(e43285).
Pollock W. T cell immunophenotyping distinguishes active from latent tuberculosis. J Infect Dis. 2013;952–68.
Aditama MPZ. Faktor yang mempengaruhi kesembuhan penderita tuberkulosis Paru. Dep Pulmonologi Dan Ilmu Kedokt Respirasi FKUI-RSUP Persahabatan Jakarta. 2013.
Authors who publish with this Journal agree to the following terms: (Download Copyright Notice)
1. Author retains copyright and grants the journal right of first publication with the work simultaneously licensed under a creative commons attribution license that allows others to share the work within an acknowledgment of the work’s authorship and initial publication of this journal.
2. Authors are able to enter into a separate, additional contractual arrangement for the non-exclusive distribution of the journal’s published version of the work (e.g. acknowledgment of its initial publication in this journal).
3. Authors are permitted and encouraged to post their work online (e.g. in institutional repositories or on their websites) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published works.
4. User/public use of this website will be licensed to Creative Commons Attribution-ShareALike 4.0 International (CC BY-SA 4.0) License.
